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Morphology, Secretion, and Transplantability of Ten Mouse Ovarian Neoplasms Induced by Intrasplenic Ovarian Grafting^*

( Department of Anatomy, University of North Carolina, Chapel Hill, N.C.)

Intrasplenic grafts of ovaries in young adult, gonadectomized CHI mice produced ovarian neoplasms in four of ten male and ten of seventeen female hosts.

One year or more after the intransplenic grafts were made, fragments from ten of the neoplasms were transplanted subcutaneously into related hosts. Six of these transplanted neoplasms grew readily, and their morphology and hormone secretion pattern, as indicated by the histology of various target organs, was studied. The morphology of these neoplasms proved to be an inadequate index to the quality of their secretion. Neither the morphology of the primary tumor or its secretory capacity seemed to influence the predictability of successful primary subpassage.

On this basis of this investigation and reports of other investigations, it is postulated that neoplasms arising from ovaries grafted intrasplenically achieved autonomy 9–12 months after grafting.

^* This investigation was supported by Grant C-2246 M & G from the National Cancer Institute, Public Health Service.

Received 7/ 2/56.