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Host-induced Alterations in Strain Specificity of Sarcoma I in Mice: Effect of Active Immunization of the Host^*

( Waldemar Medical Research Foundation, Port Washington, N.Y.)

Passage of a mouse tumor graft, Sarcoma I from A/He mice, through C57BL/6Jax mice, actively immunized with whole nonviable Sarcoma I tumor antigen, resulted in a biologic modification of the tumor graft.

The modification of the tumor was evidenced by progressive growth of the altered tumor in serial passages in normal adult mice of three genetically unrelated inbred strains.

Sarcoma I tissue from immunized C57BL/6Jax mice showed progressive evidence of anaplasia on being transplanted from the immunized C57BL/6Jax mice to normal C3H, C57BL/6Jax, and BALB/c mice. The tumor tended to revert to its original morphology when transplanted back to A/He mice from the subline passages in the three unrelated mouse strains.

The sarcoma graft established in C3H mice, when transplanted in serial passage to normal A/He mice and then back to normal C3H mice, grew progressively, and all mice of both strains died with large tumors.

A variant of Sarcoma I, designated as Sarcoma Mo, has been described.

^* This study was supported in part by a grant from the United States Public Health Service of the National Institutes of Health and, in part, by funds from the Vernet Foundation of Yellow Springs, Ohio, The Braskin Foundation of Chicago, and the J. W. Stark Foundation of Sands Point, N.Y.

Received 7/14/56.