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The Distribution of Radioactivity Following Administration of Triethylenephosphoramide-P³² in Tumor-bearing and Control Mice^*

Moreshwar V. Nadkarni, Edwin I. Goldenthal and Paul K. Smith

( Department of Pharmacology, George Washington University School of Medicine, Washington, D.C.)

1. A study was made of the excretion and tissue distribution of radioactivity following intraperitoneal administration of TEPA-P³² to control mice and to mice bearing Lymphosarcoma 1, Sarcoma 37, or Leukemia 1210.

2. A major portion of the injected radioactivity was excreted in the urine and feces within 24 hours. The major urinary metabolite was inorganic phosphate. A small percentage was excreted as an organic phosphorus compound assumed to be an intermediate between TEPA and inorganic phosphate. No TEPA was excreted unchanged.

3. There was no marked selective localization of radioactivity in the various organs of tumor-bearing mice as compared with that in control animals.

4. The group of mice bearing Lymphosarcoma 1 retained a larger proportion of radioactivity than did the control mice or mice bearing Sarcoma 37 or Leukemia 1210.

^* This investigation was supported in part by a grant from the American Cancer Society (F-129 A), in part by the Damon Runyan Memorial Fund for Cancer Research (DRIR-42E), and in part by a grant from the National Institutes of Health (C-308).

Present address: Division of Pharmacology, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C.

Received 8/27/56.