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Influence of Glucose Antimetabolites on the Walker Tumor^*

( Biological Research Institute, San Diego Zoological Society, San Diego, and Scripps Clinic and Research Foundation, La Jolla, Calif.)

1. The intraperitoneal, divided-dose administration of glucosamine hydrochloride, 400–600 mg/rat/day (approximates 2,000–3,000 mg/kg/day) or 2-deoxy-D-glucose 200 mg/rat/day (approximates 1,000 mg/kg/day) exerted an antitumor effect in rats bearing Walker 256 tumor, without seriously compromising the general well being of the host.

2. The antitumor effect of 2DG was somewhat greater than that of glucosamine at – the glucosamine dosage level.

3. Changes in rate of tumor growth between treatment and nontreatment periods were significant when 2DG was used.

4. The modified metabolic environment created by the presence of 2DG was rather quickly changed after cessation of administration, with resumption of tumor growth to a rate approaching that of controls.

^* Supported in part by a grant from the California Division, American Cancer Society.

Received 11/20/56.