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Studies on OPSPA

IV. Metabolism of OPSPA in the Rat and Human^*

( McArdle Memorial Laboratory, The Medical School, University of Wisconsin, Madison 6, Wis.)

1. The metabolic conversions of C¹⁴- and P³²-labeled OPSPA into morpholine, MEPA, and inorganic phosphate have been demonstrated by carrier crystallization and chromatographic procedures.

2. In rats the primary metabolite was MEPA, little unchanged OPSPA was found, and there was cleavage to morpholine and inorganic phosphate.

3. In humans considerable MEPA was produced, but there was a greater quantity of unidentified metabolites. There was more production of inorganic phosphate than of morpholine in humans.

^* This work has been supported in part by grants-in-aid from the Wisconsin Division of the American Cancer Society and the Lederle Laboratories; by an Institutional Grant, INSTR-71, from the American Cancer Society; and by grant C-2409 from the National Cancer Institute, National Institutes of Health, Public Health Service.

A preliminary account of part of this work appeared in Proc. Am. Assoc. Cancer Research, 2(2):130, 1956.

Received 9/ 4/56.

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