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Papilloma Formation in the Forestomach of the Mouse Following Oral Administration of Urethan (Ethyl Carbamate)

( Department of Experimental Biology, Isaac Wolfson Building, Weizmann Institute of Science, Rehovoth, Israel)

The administration of large doses of urethan (ethyl carbamate) to Swiss strain mice by stomach tube led to the development of multiple papillomas of the squamous epithelium of the forestomach.

Spontaneous solitary papillomas of the forestomach were observed in a small proportion of control mice of this strain.

Received 11/26/56.