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Chemotherapeutic Studies with Transplants of Spontaneous Mammary Tumors of Mice Growing in Various Hosts^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute and the Sloan-Kettering Graduate Division of Cornell Medical College, New York, N.Y., and the Division of Cancer Biology, Department of Pathology, University of Minnesota, Minneapolis, Minn.)

1. It has been shown that, irrespective of the hosts employed, first- and second-generation transplants of spontaneous mammary tumors of Z mice respond alike to chemotherapeutic agents. Three compounds, STEPA, ARDMA, and F-Ac, are effective in inhibiting such transplants whether they are grown in Z, Zb, AZF₁ hybrids, or Z backcross mice.

2. It has been shown that the poor response of spontaneous mammary cancers of mice to agents that are effective against transplants of these tumors may be a general phenomenon. This difference has been seen in each of three inbred strains of mice, namely, the A, C, and Z strains.

3. It seems unlikely that immunogenetic factors play a major role in the response to chemotherapeutic agents of the transplanted tumors employed herein.

^* This work was supported in part by grants C 415 and C 2468 from the National Cancer Institute of the National Institutes of Health, Public Health Service; by a grant from the Elsa U. Pardee Foundation; by the Minnesota Division, American Cancer Society, Inc.; and by the American Cancer Society, Inc., upon recommendation by the Committee on Growth of the National Research Council.

Received 1/21/57.