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Observations on the Action of Azaserine in Mammalian Tissues^*

( McArdle Memorial Laboratory and the Cancer Research Hospital, University of Wisconsin, Madison 6, Wis.)

Correlation between the biological effect of azaserine in inhibiting growth of solid tumor implants and its biochemical inhibition of de novo purine synthesis has been obtained.

Assays of both human and mouse blood after a single dose of azaserine have been performed to determine the rate of removal of this drug from the blood stream. This process is very rapid in mice but considerably slower in humans.

It has been suggested that side effects seen in humans treated with azaserine are due to this slow rate of removal of the drug from the blood. In mice, in which such side effects are not observed, azaserine is eliminated from the blood very rapidly.

^* This research was supported in part by the United States Public Health Services Grant No. C2491 and in part by the Alexander and Margaret Stewart Fund.

Received 1/31/57.