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Correlation of Serum Lactic Dehydrogenase Activity with the Clinical Status of Patients with Cancer, Lymphomas, and the Leukemias

( Medical Research Institute and Hospital for Tumors and Allied Diseases, City of Hope Medical Center, Duarte, Calif.)

1. The LDH activity of the serum from 615 patients and volunteers has been determined. The normal adult range of LDH activity lies between 0.060 and 0.110 optical density. Children up to and including the age of 14 have LDH activities from 0.125 to 0.210.

2. Eighty-four of 91 patients with leukemias had elevated LDH values of 0.115 or above. Six of the remaining seven patients were under active treatment for their leukemia.

3. One hundred forty-four of 206 patients with proved cancer and lymphomas had LDH values of 0.115 or above. Twenty of the remaining 62 patients with low LDH values were under active treatment at the time of sampling.

4. Although the serum LDH activity is not a certain indicator of the presence or absence of a neoplastic process, its increased activity in the serum of patients with the leukemias and in normal children suggests a relationship between LDH activity and growth.

5. The LDH activity in the serum closely paralleled the clinical status of seven patients with leukemia.

Received 2/16/57.