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Human Cell Culture. Morphology of the Detroit Strains^*

Lawrence Berman, Cyril S. Stulberg and Frank H. Ruddle

( Department of Pathology, Wayne State University College of Medicine, Detroit 7, Michigan, and the Child Research Center of Michigan, Detroit 2, Mich.)

The similarities of various Ep-L cell strains derived from cancerous and noncancerous human sources have been described. Variations in cell morphology, polyploidy, and heteroploidy have been found to exist in similar degree in all strains. The morphogenesis of Ep-L cells from Fb-L cells was pointed out, and attempts to identify cell types by various methods were described. The significance of the findings was discussed.

^* These investigations were supported by grants from the National Institutes of Health, Public Health Service (CY-2947); Receiving Hospital Research Corporation (P-15A); and institutional grants from the American Cancer Society, Inc., and the American Cancer Society, Southeastern Michigan Division.

Presented in part before the Section of Biology, New York Academy of Sciences, New York City, February 11, 1957.

Present address: Department of Zoology, University of California, Berkeley, California.

Received 2/18/57.

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