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Biochemical Screening of Pyrimidine Antimetabolites

III. The Testing of Drugs against a System with a Nonoxidative Energy Source^*

Joseph E. Stone and Van R. Potter

( McArdle Memorial Laboratory, The Medical School, University of Wisconsin, Madison 6, Wis.)

Seventeen drugs which demonstrated in vitro inhibitory activity against an oxidative system for the conversion of orotic acid to the uridine nucleotides were retested against a nonoxidative system. The 5-bromo, 5-chloro and 5-fluoro analogs of orotic acid were demonstrated to produce single or multiple blocking actions against this system.

^* This work was supported in part by a grant (No. C2409) from the National Cancer Institute, National Institutes of Health, United States Public Health Service.

Present address: General Medical Research, Veterans Administration Research Hospital, 333 East Huron Street, Chicago 11, Ill.

Received 4/29/57.