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Biochemical Studies of the Ehrlich Ascites Carcinoma-Bunyamwera Virus System

( Viral and Rickettsial Section, Research Division, American Cyanamid Company, Pearl River, N.Y.)

1. Ehrlich ascites carcinoma cells were shown to be deficient in the enzymes choline oxidase, xanthine oxidase, alkaline phosphatase, and deoxyribonuclease.

2. Infection of Ehrlich ascites cells with Bunyamwera virus was without effect at any stage of the infectious process on the succinoxidase, malic dehydrogenase, hexokinase, acid phosphatase, ß-glucuronidase, and glycolytic activities of the cells.

3. The arginase activity of Ehrlich cells was stimulated during the first 30 hours of infection with Bunyamwera virus. Thereafter, the activity diminished until, terminally, it was significantly lower than normal.

4. At intervals of 24 and 48 hours after infection of Ehrlich cells with Bunyamwera virus, the arginine content of the "total" cell protein was lower than that of uninfected cells but was higher than that of uninfected cells 72 hours post-infection.

Received 5/27/57.