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A Study of Mitosis in Cervical Epithelium during Experimental Inflammation and Carcinogenesis^*

D. G. Scarpelli and E. von Haam

( Department of Pathology, Ohio State University, Columbus, Ohio)

1. Although a few mitotic abnormalities were found in inflammatory cervical lesions, ever increasing numbers were observed during the pathogenesis of experimentally induced cervical cancer.

2. Lagging chromosomes constituted the most frequent mitotic abnormality. Polar chromosomes were found only in malignant cervical lesions.

3. Changes in the frequency and/or length of prophase and metaphase were observed which sharply differentiated benign from malignant lesions during the pathogenesis of cancer.

4. The critical prophase indices which were diagnostic of malignancy ranged from 2.15 to 2.56 or above, depending on the number of either prophase or metaphase mitoses counted.

^* Presented in part at the International Cytology Congress, Chicago, Ill., October 11, 1956.

This study was aided by grant C-2704-R from the National Institutes of Health, U.S. Public Health Service.

National Science Foundation Postdoctoral Fellow in Pathology.

Received 5/13/57.

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