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Active Transport of O-diazoacetyl-L-serine and 6-Diazo-5-oxo-L-norleucine in Ehrlich Ascites Carcinoma^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research; and Sloan-Kettering Division, Cornell University Medical College, New York, N.Y.)

1. Azaserine and DON are concentrated intracellularly in Ehrlich ascites cells by the amino acid active transport system.

2. The intracellular-extracellular concentration gradient attained in this concentration process is greater than that reported for all the "normal" amino acids.

^* This work was supported in part by an institutional grant from the American Cancer Society and by Grant C-678 (C8) from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

Received 5/18/57.