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Influence of the Duration of Treatment with A-Methopterin on the Survival Time of Mice with Advanced Leukemia (L1210)

( Laboratory of Chemical Pharmacology and Biometry Branch, National Cancer Institute, Bethesda, Md.^*)

In the treatment of advanced mouse leukemia L1210 with daily injections of A-methopterin, it was found advantageous to continue the treatment indefinitely. Whenever daily treatment was discontinued, the leukemic mice succumbed, on the average, in 2–3 days. The data suggest that the failure to derive any benefit from the discontinuance of treatment resulted from the inability to obtain sufficiently extensive regression of advanced tumors with regimens of treatment which are not lethal to the host.

^* National Institutes of Health, U.S. Public Health Service, Department of Health, Education, and Welfare.

Received 6/ 7/57.