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The Effect of Estradiol and Cortisol on the Transplantability and Subsequent Fate of Normal, Hyperplastic, and Tumorous Mammary Tissue of C3H Mice^*

( Department of Zoology and Its Cancer Research Genetics Laboratory, University of California, Berkeley, Calif.)

Fragments of normal mammary gland, individual hyperplastic alveolar nodules, and portions of tumors were isolated from donor C3H/He CRGL mice and transplanted to an area free of mammary tissue in young virgin female hosts of the same strain. Each group of three transplants was taken from a single donor and transplanted into a single host. Inasmuch as the recovery rate after periods of 2, 4, and 12 weeks was greater than 85 per cent, this method provides a practical means of studying changes in the mammary gland.

Cortisol stimulated increased secretion in the nodules and in some tumors. Estradiol resulted in an increase in connective tissue in normal and nodule transplants.

A few of the transplanted portions of the normal mammary gland became nodules, and some of the transplanted nodules appeared to have reverted to normal mammary tissue. Within the 12-week limit of this experiment only one of a total of 127 nodules transplants showed any evidence of possible neoplastic change.

^* This study was aided by the University of California Cancer Research Fund. Submitted as the thesis in partial satisfaction of the requirements of the M.A. degree.

Received 7/ 8/57.