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The Carcinogenicity of Creosote Oil: Its Role in the Induction of Skin Tumors in Mice^*

( McArdle Memorial Laboratory, Medical School, University of Wisconsin, Madison, Wis.)

1. Mice were treated with 9,10-dimethyl-1,2-benzanthracene (DMBA), creosote oil, or croton oil, alone or in several combinations of two of the agents. The incidence of papillomas and carcinomas as well as the tumor induction time of each were reported.

2. The effective nature of creosote as a skin carcinogen was confirmed, and its ability to act as an initiating agent prior to applications of croton oil was shown.

3. The average induction times for papillomas and carcinomas by the different treatments were found to vary independently.

^* This work was supported in part by grants from the Alexander and Margaret Stewart Trust Fund and from the American Cancer Society.

Received 5/ 5/58.