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The Use of Anaerobes and Respiratory-deficient Yeast Mutants as a Screening Procedure for Potential Tumor-inhibiting Agents^*

( Roswell Park Memorial Institute, Buffalo, N.Y.)

1. Compounds of known cancer therapeutic value as well as cell metabolites and natural products were studied for their capacity to inhibit clostridia and induced respiratory mutants of several yeasts.

2. The use of clostridia in screening for cancer chemotherapeutic agents was no more successful than experiments with E. coli. At the present time, strict anaerobes appear to have limited value in a screening program.

3. Although a large number of compounds known to inhibit animal tumors has not been effective against yeast respiratory mutants, the value of respiratory mutants in cancer screening programs requires further study.

^* This investigation was supported in part by a research grant CY-3553, from the National Cancer Institute, National Institutes of Health, U. S. Public Health Service.

Presented in part at the 49th Annual Meeting of the American Association for Cancer Research, Philadelphia, Pa., April 11–13, 1958.

Received 6/16/58.