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Urethan (Ethyl Carbamate) as a Multipotential Carcinogen^*

Albert Tannenbaum and Herbert Silverstone

( Department of Cancer Research, Medical Research Institute, Michael Reese Hospital,^, Chicago 16, Ill.)

1. Long-term application of a solution of 20 per cent urethan in acetone was made to the skin of the interscapular area of (C57BL x C3H )F₁, DBA, and C3H mice. This chronic treatment was continued for periods ranging up to 18 months and total amounts of urethan as high as 1800 mg/mouse.

2. Urethan did not evoke skin tumors at the site of application.

3. However, five separate and distinct lesions were induced or potentiated by the long-term application of urethan to the skin of the mice: pulmonary adenomas, mammary carcinomas, malignant mesenchymal tumors in the interscapular fat, cystadenomas of the lacrimal gland, and blood cysts in the liver.

4. Urethan is a multipotential carcinogen.

^* This work was supported by research grants from the Damon Runyon Memorial Fund (DRG-250) and the U.S. Public Health Service (C-3787).

Deceased May 31, 1956.

Supported, in part, by the Foundation for Cancer Research, Chicago, and its affiliates: Bertha Adlerblum Memorial Cancer League and Mildred Lasser Balter Cancer Memorial.

Received 6/30/58.