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Carcinostatic Action of Polycarbonyl Compounds and Their Derivatives

IV. Glyoxal Bis(thiosemicarbazone) and Derivatives^*

( Research Laboratories, Mount Zion Hospital and Medical Center, San Francisco, Calif.)

1. Glyoxal bis(thiosemicarbazone) and a number of its derivatives were inhibitory to Sarcoma 180 in Swiss mice.

2. The bis(N⁴methylthiosemicarbazones) of hydroxymethylglyoxal, methylglyoxal, and ethoxymethylglyoxal were the most active members of the series reported.

3. Early or, especially, prophylactic treatment resulted in a marked and persistent incidence of "non-takes" of the tumor transplants.

4. A possible mechanism of action based on heavy metal chelation is discussed.

^* Supported in part by grants-in-aid from the American Cancer Society and the Damon Runyon Memorial Fund for Cancer Research.

Received 7/ 2/58.

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