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Inhibition of Azo Dye Carcinogenesis by Thorotrast and Iron Oxide^*

J. D. Spain and C. C. Clayton

( Department of Biochemistry, Medical College of Virginia, Richmond, Va.)

The development of liver tumors in rats by the feeding of 4-dimethylaminoazobenzene or 3'-methyl-4-dimethylaminoazobenzene was inhibited by the intravenous administration of Thorotrast or colloidal iron oxide. The inhibition occurred, even though the colloids had little effect upon riboflavin or total azo dye concentration in the liver.

^* A portion of a thesis submitted by J. D. S. in partial fulfillment of the requirements for the M.S. degree, 1953. Presented in part at the annual meeting of the American Society of Biological Chemists, Atlantic City, New Jersey, published in Fed. Proc., 13:193, 1954.

Supported in part by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and by research grant C-1541 of the National Cancer Institute of the National Institutes of Health, Public Health Service.

Present address: Dept. of Chemistry, Michigan College of Mining and Technology, Houghton, Mich.

Received 8/ 5/57.