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Carcinostatic Action of Polycarbonyl Compounds and Their Derivatives

I. 3-Ethoxy-2-ketobutyraldehyde and Related Compounds^*

( Research Laboratories, Mount Zion Hospital, San Francisco, Calif.)

1. 3-Ethoxy-2-ketobutyraldehyde (Kethoxal®) increases, consistently, the life span of mice with Leukemia L1210.

2. Phenylglyoxal, cyclohexylglyoxal, methoxy-methylglyoxal, glyoxal, succinaldehyde, and malonaldehyde also showed some antileukemic activity.

3. Relationships among structure, activity, and side effects are discussed.

^* Supported in part by grants-in-aid from the American Cancer Society and the Damon Runyon Memorial Fund for Cancer Research.

Received 8/12/57.

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