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The Biology of Testicular Cancer

II. Endocrinology of Transplanted Tumors^*

Barry Pierce, Frank J. Dixon, Jr. and Ethel Verney

( University of Pittsburgh School of Medicine, Pittsburgh 13, Pa.)

1. The characteristics of a second heterotransplantable human testicular choriocarcinoma, PITT 100, are described.

2. Two permanently heterotransplantable choriocarcinomas, PITT 89 and PITT 100, are permanently functional, producing chorionic gonadotrophin in their new hosts.

3. One variant of an embryonal carcinoma demonstrated an increased growth rate and was associated with uterine hyperplasia in the host.

^* This investigation was supported in part by the Martha O. Freas Grant-in-Aid No. M.O.F.-7A, American Cancer Society; and the United States Public Health Service Grant No. CY-3297.

This is publication No. 126 from the Department of Pathology, University of Pittsburgh School of Medicine.

Sarah Mellon Scaife Fellow in Pathology, University of Pittsburgh School of Medicine.

Received 8/29/57.

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