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The Effect of Methylcholanthrene on the Denervated Skin of Strain A Mice^*

Jack Hasson

( Laboratory Division, Montefiore Hospital, New York 67, N.Y.)

The effect of methylcholanthrene on the denervated skin of Strain A mice was studied. A band of skin was denervated by the unilateral resection of the lower six thoracic dorsal root ganglia in continuity with dorsal and ventral nerve roots and peripheral nerve trunks. Suitable controls indicated that methylcholanthrene caused a more rapid appearance of tumors in the mice with denervated skin. The possible mechanisms for this are discussed.

^* This investigation was done while the author was a Trainee in Neuropathology of the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service. The work was supported in part by the National Multiple Sclerosis Society.

Present Address: The Jewish Hospital of St. Louis, Mo.

Received 8/ 2/57.