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Effect of Nikethamide (Coramine) on Incorporation of Radioactive Phosphate into Rat Liver Deoxypentosenucleic Acid^*

Willis R. Foster and Fred G. Brazda

( Department of Biochemistry, Louisiana State University, School of Medicine, New Orleans, La.)

1. Dietary Coramine significantly increased the specific activity of the deoxypentosenucleic acid (DNA) of the weanling rat liver cell nucleus after injection of radioactive phosphate. This is considered to be evidence that the increase in liver weight observed is associated with increased synthesis of DNA and, therefore, involves growth of new tissue.

2. Total DNA/experimental liver was increased over the control.

3. The concentration and specific activity of the total nucleic acid phosphorus were increased while those of the acid-soluble phosphorus were decreased by Coramine.

4. The present results suggest that Coramine causes an increased growth of essentially normal liver tissue in the young growing rat.

^* This work was done with the support of predoctoral fellowship AF 5192 of the National Institutes of Health, Division of Research Grants, and the report was taken from a thesis by W. R. Foster for the M.S. degree in Biochemistry.

Present address: The George Washington University School of Medicine, Washington, D.C.

Received 10/ 8/57.