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Can the Inbred Mouse Be Immunized against Its Own Tumor?^*

Herbert M. Hirsch, John J. Bittner, Harvey Cole and Iver Iversen

( Division of Cancer Biology, Department of Pathology, University of Minnesota Medical School, Minneapolis 14, Minn.)

In attempts to isoimmunize inbred strain C mice with the use of a tumor of recent spontaneous origin as the immunizing agent, no differences in the total number of tumors or in the times of appearance of the tumors were found between experimental and control groups. The pretreated mice exhibited, however, a small but significant increase in survival time as compared with the controls. The data thus show that the inbred mouse can be immunized against tumors of its own strain of recent origin, but that the extent of immunity thus achieved is a rather small and subtle one. The mechanisms underlying the immune phenomena observed remain to be elucidated.

^* Assisted by grants from the National Cancer Institute of the National Institutes of Health, Public Health Service; the American Cancer Society, upon recommendation of the committee on Growth of the National Research Council; the Minnesota Division of the American Cancer Society; and the Damon Runyon Cancer Research Fund.

Scholar in Cancer Research of the American Cancer Society.

Received 10/28/57.