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Further Studies of Chemotherapeutic Agents in Spontaneous Mammary Adenocarcinomas of Mice and in Transplants of Recent Origin^*

Jean Scholler and John J. Bittner

( Div. of Experimental Chemotherapy, Sloan-Kettering Inst. and Sloan-Kettering Graduate Division of Cornell Medical College, New York, N.Y., and the Div. of Cancer Biology, Dept. of Pathology, University of Minnesota, Minneapolis, Minn.)

The present results were consistent with others which we have published previously (14). Spontaneous mammary tumors of mice proved more resistant to chemotherapeutic agents than did first- or second-generation transplants of such tumors. Agents such as 6-diazo-5-oxo-L-norleucine (DON), 4-aminopyrazolo-(3,4-d)-pyrimidine (4-APP), and 1-methyl-4-aminopyrazolo-(3,4-d)-pyrimidine (1-Me-4-APP) were highly active (++) in the recent transplants, while at best only slightly active (±) in the spontaneous tumors. This slight activity was obtained with doses which were toxic as evidenced either by a decrease in survival time or by weight loss in the treated animals. Though N-desacetylthiocolchicine, 3,3-dimethyl-1-phenyltriazene, 2-ethylamino-1,3,4-thiadiazole hydrochloride, and 1,9-di(methanesulfonoxy)nonane have been reported active in certain long-established transplanted tumors, they were unimpressive in the present first-and second-generation transplants and in spontaneous mammary tumors. Neither zymosan nor 4-(p-dimethylaminostyryl) quinoline methiodide inhibited the growth of either the transplants or the spontaneous tumors. Finally, ribonuclease and 1,2-dimethyl-4-amino-5-hydroxybenzene have not been found to inhibit the growth of the spontaneous mammary tumors used in the present study.

^* This work was supported in part by grants C 415 and C 2468 from the National Cancer Institute of the National Institutes of Health, Public Health Service; by a grant from the Elsa U. Pardee Foundation; by the Minnesota Division, American Cancer Society, Inc.; and by the American Cancer Society, Inc., upon recommendation by the Committee on Growth of the National Research Council.

Present address: Institute of Medical Research, The Christ Hospital, Cincinnati 19, Ohio.

Received 12/20/57.