This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Porta, G. D. Articles by Shubik, P. Search for Related Content PubMed PubMed Citation Articles by Porta, G. D. Articles by Shubik, P.

Induction of Tracheobronchial Carcinomas in the Syrian Golden Hamster^*

( Division of Oncology, Chicago Medical School, Chicago, Ill.)

1. A technic has been described for the direct endotracheal introduction of carcinogens in the Syrian golden hamster.

2. In experiments with repeated endotracheal instillations of 9,10-dimethyl-1, 2-benzanthracene in a colloidal suspension, hyperplasia, squamous metaplasia, atypical changes of the tracheobronchial epithelium, squamous-cell and adenocarcinomas of the trachea and bronchi have been produced.

3. Administration of tobacco tar, also as a colloidal suspension, produced no histologically demonstrable lesions.

^* This investigation was supported by research grant L-4B from the American Cancer Society, Inc., and Cancer Control Grant CS-9212 from the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service.

Received 12/26/57.

This article has been cited by other articles:

				R. A. Renne and K. M. Gideon Types and Patterns of Response in the Larynx Following Inhalation Toxicol Pathol, April 1, 2006; 34(3): 281 - 285. [Abstract] [Full Text] [PDF]

				J. Little, A. Kennedy, and R. McGandy Lung cancer induced in hamsters by low doses of alpha radiation from polonium-210 Science, May 16, 1975; 188(4189): 737 - 738. [Abstract] [PDF]