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The Effect of Croton Oil and Carcinogens on Mitosis and the Deoxyribonucleic Acid Content of Cervical Epithelial Cells^*

D. G. Scarpelli and Emmerich von Haam

( Department of Pathology, Ohio State University, Columbus, Ohio)

1. Microspectrophotometric analysis of nuclear DNA and mitotic counts revealed that a correlation exists between increased nuclear DNA and augmented mitoses, or mitotic rate.

2. Endocervical application of croton oil or 20-methylcholanthrene resulted in augmented mitoses and increased exfoliation of epithelial cells containing greater amounts of nuclear DNA.

3. Distinct differences appear to exist between the mitogenic effect of croton oil and methylcholanthrene on the genital epithelium of the mouse.

4. Marked increases in the mitotic rate and nuclear DNA (polyploidy) were observed in many malignant cells.

^* This investigation was supported in part by Research Grant C-2148 from the National Cancer Institute and C-2704R from the National Institutes of Health, USPHS.

National Science Foundation Postdoctoral Fellow in Pathology.

Received 1/ 1/57.