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Reactions of Antisera Prepared against HeLa Cells and Normal Fetal Liver Cells with Adult Human Tissues^*

( Department of Biochemistry Research and Experimental Biology, Roswell Park Memorial Institute, Buffalo, N.Y.)

The reactions of antibodies prepared in rabbits against tissue culture cells of human origin (HeLa and fetal liver) with human thyroid, liver, kidney, and adrenal were studied by the immunohistochemical staining technic involving fluorescein as a label. Both sera acted similarly and stained stromal elements, i.e., reticular tissues, basement membranes, and sinusoidal linings. Thus, the tissue-cultured cells of both lines contained components in common with or closely related to those of stromal elements of normal tissue.

^* Supported by Grant C-2746 of the National Cancer Institute and Grant H-2092 of the National Heart Institute, U.S.P.H.S.

Received 11/14/57.