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Glutathione Reductase and Lactic Dehydrogenase Activities of Tissues of Rodents with Transplanted Tumors

( Division of Enzyme and Metabolic Studies and Division of Experimental Chemotherapy, Sloan-Kettering Inst., Memorial Center for Cancer and Allied Diseases, New York 21, N.Y.)

Transplanted malignant tumors in mice and rats were associated with increased plasma GR and LD activities, the latter enzyme increments appearing sooner after implantation of tumor cells and reaching levels quantitatively greater than the former. Regeneration or rapid growth of nonmalignant hepatic tissue was unassociated with plasma GR and LD alterations. The relationship between alterations in plasma GR and LD activities and tissue enzyme activity was not apparent.

Received 1/13/58.

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