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Use of the Housefly as a Screening Agent for Tumor-inhibiting Agents

( Entomology Research Division, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Md.)

Twenty-six growth-inhibiting compounds used in a study reported by Gellhorn and Hirschberg (1955) on diverse biological systems were tested on the housefly (Musca domestica L.) to determine whether that organism could be used for screening potential tumor-inhibiting drugs. Growth of the ovaries was used as a criterion. Fifteen of the materials caused inhibition of ovarian growth. The results show that, with further refinement in the method, the housefly, an easily and cheaply reared organism, may take its place as one of the primary screening agents in cancer chemotherapy.

Received 2/ 5/58.

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