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Urethan and Leukemogenesis in Mice^*

S. Kawamoto, N. Ida, A. Kirschbaum and G. Taylor

( Department of Anatomy, Baylor University College of Medicine, and Department of Pediatrics, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas)

1. Urethan augmented the induction of leukemia in mice by x-rays, estrogenic hormone, or methylcholanthrene.

2. Urethan was not leukemogenic for low-leukemia strains of mice when administered alone in doses which remarkably augmented the leukemogenic activity of other agents.

3. The protective effects upon leukemia induction of shielding bone marrow were nullified if mice were anesthetized with urethan during x-radiation.

^* This investigation has been supported by grants from the National Cancer Institute, Public Health Service, and the American Cancer Society.

Deceased.

Received 2/10/58.

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