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Experimental Carcinoma of the Colon^{* ,}

( Department of Pathology, Ohio State University, Columbus, Ohio)

1. The insertion of 20-methylcholanthrene-impregnated cotton string through an appendicostomy into the ceco-appendix of 62 male albino rats elicited a chronic inflammatory process in this organ, which was accompanied in most instances by epithelial dysplasia. During the course of the experiment, nine intra-epithelial carcinomas and nineteen invasive carcinomas of the ceco-appendix were identified on histologic sections.

2. The development of these lesions was followed by weekly fecal smears which were classified into three pathologic categories: (a) inflammatory, (b) dysplastic, and (c) suspicious for malignancy. The individual fecal smear was found helpful for a diagnosis of inflammation accompanied or unaccompanied by epithelial dysplasia. The analysis of the series of successive smears from each individual animal permitted a reasonably accurate evaluation of the nature and stage of the pathologic process in the ceco-appendix of the experimental animals.

^* Presented in part at the International Cancer Cytology Congress, October 8, 1956, Chicago, Illinois.

This work was supported in part by a grant of the American Cancer Society and by a grant from the National Cancer Institute.

Received 7/15/57.