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Seroflocculant Activity of Ethyl Choladienate and Various Alcohols in the Penn Test for Cancer^*

( Department of Radiology, University of California at Los Angeles Medical Center, Los Angeles 24, Calif.)

The substance in serum of individuals with cancer and other diseases which gives a positive seroflocculation reaction with ethyl choladienate has been characterized as C-reactive protein. Batyl alcohol gives an analogous reaction in the presence of C-protein. Flocculating properties are also associated with hexadecanol and a variety of other alcohols which were examined. No evidence has been obtained for the consistent presence of another substance in cancer serum giving a flocculation reaction with either ethyl choladienate or batyl alcohol. This reaction involving C-protein offers little hope for exploitation as a means of diagnosis of early cancer.

^* Supported by Cancer Research Funds of the University of California and in part by a grant from the U.S. Public Health Service.

Received 2/ 4/58.