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Cytopathogenic Effects of Ethylenephosphoramides upon the Walker 256 Rat Tumor^*

( Bureau of Biological Research, Rutgers University, New Brunswick, New Jersey, and the Special Dental Research Program, Veterans Administration Hospital, Brooklyn, N.Y.)

Cytopathogenic effects following treatment of Walker 256 tumors with ethylenephosphoramide drugs have been described. The changes consisted of the appearance of bizarre, polymorphic, giant cells with distorted nuclear and cytoplasmic configurations and unusual staining properties. Among specific cellular processes that may be affected are those concerned with nucleic acid metabolism, mitosis, and nuclear-cytoplasmic solgel equilibria.

^* These studies have been supported in part by American Cancer Society Grant T-50.

Received 3/18/58.