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The Inhibition by Guinea Pig Serum of the Growth of the Murphy-Sturm Lymphosarcoma^*

Eloise Jameson, Herman Ainis and R. Mark Ryan

( University of Southern California, Department of Medicine, Los Angeles, Calif.)

Intraperitoneal injections of guinea pig serum are more effective in inhibiting growth of the solid form of the Murphy-Sturm lymphosarcoma carried in Wistar rats when there is a latent period of at least 5 days. Disparities between two groups of animals that have shorter and longer latent periods, respectively, are manifested by differences in: (a) the number of tumors that are completely inhibited, (b) the length of the latent period, and/or (c) the number of tumor regressions.

Intraperitoneal injections of guinea pig serum are shown to be effective in inhibiting growth of the more virulent ascites form of this tumor.

^* Supported in part by Mr. and Mrs. John J. Elmore and the University of Southern California, Department of Medicine. We are indebted to the Hancock Foundation for laboratory space and facilities.

Present address: Department of Chemistry, California Institute of Technology, Pasadena, California.

Received 4/11/58.