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Host-induced Alterations in Strain Specificity of Sarcoma I in Mice: Reversibility of the Change^*

( Waldemar Medical Research Foundation, Port Washington, N.Y.)

1. The reversibility of the alteration in the strain specificity of Sarcoma I, induced by passage through actively immunized C57BL/6 mice, has been studied.

2. The altered Sarcoma I (Sarcoma I/Mo) was serially transplanted during a 2-year period in normal adult mice, both sexes, in 533 C3H, 457 BALB/c, and 364 C57BL/6 mice.

3. In each of the strains studied the adapted Sarcoma I/Mo established itself in a relatively constant "take" ratio, i.e., 92.3 per cent in C3H, 92.6 per cent in BALB/c, and 73.8 per cent in C57BL/6.

4. Sarcoma I/Mo continued to change when resident as a homotransplant, as evidenced by the acquisition of capacity to "take" in C57BL/6 mice only after residence in C3H and in BALB/c serial passages.

5. The acquired homotransplantability was reversible: A strain specificity was gradually regained when the Sarcoma I/Mo was returned to and carried in serial passages in A strain mice.

6. Given a changing, adverse, but nonlethal environment a mouse cancer graft, Sarcoma I, was induced to acquire several new compatibilities.

^* Supported in part by grants from the National Institutes of Health, Department of Health, Education and Welfare (Grant C-1658 C5); the Vernay Foundation, Yellow Springs, Ohio; and the Louis A. and Hazel Breskin Foundation, Chicago, Illinois.

A portion of these data was reported at the American Association for Cancer Research, April, 1957.

Received 3/24/58.

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