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Mast-Cell Disruption and I¹³¹ Distribution in the Rat^*

( Department of Radiology, University of California, School of Medicine, San Francisco, Calif.)

Disruption of mast cells by the administration of distilled water, polymyxin B, compound 48/80, or tumor polypeptide derived from rat sarcoma produced alterations in I¹³¹ distribution similar to those seen in a tumor-bearing animal. Injection of two of the known mast cell components, histamine and 5-HT, also caused this alteration, called iodide trapping. Heparin had no activity in this respect. Reserpine, because of its ability to release 5-HT from the body, produced the trapping syndrome.

These factors, together with the knowledge that growth of the tumor causes a progressive, widespread decrease in the number of intact mast cells, indicate that the release of histamine and/or 5-HT resulting from this disruption of mast cells may be responsible for the iodide trapping observed in the tumor-bearing animal.

^* This work was supported by a grant from the Henry, Laura, and Irene B. Dernham Fund of the American Cancer Society, California Division, and by Cancer Research Funds of the University of California.

Received 4/ 4/58.