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Effects of Combinations of Radiation and Chemotherapeutic Agents Against Experimental Animal Tumors¹

Division of Experimental Chemotherapy and the Radiobiology Section of the Division of Physics and Biophysics Sloan-Kettering Institute for Cancer Research and the Laboratories of the Sloan-Kettering Division of Cornell University Medical College, New York, New York

Carcinomas RC and 63 and sarcoma 180 were irradiated following treatment with each of eight or nine chemicals tried separately. The only responses suggestive of synergism were with TEM on the RC carcinoma and sarcoma 180, and possibly 6-mercaptopurine on the latter tumor. It was not possible to confirm the report by others of the increased radiation damage to the Walker carcinosarcoma 256 as a result of the administration of Synkayvite prior to irradiation of the tumor.

¹ This investigation was supported by a research grant (C2389) from the National Cancer Institute of the National Institutes of Health, Public Health Service.