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A Note on the Interaction of Carcinogenic Molecules with Cellular Protein^*

( Centre de Mécanique Ondulatoire Appliquée, 155 Rue de Sèvres; and Pavillon Pasteur de l'Institut du Radium, 26 Rue d'Ulm, Paris, France)

If in giving a particular interpretation to a "K-L regions" theory it is assumed that aromatic hydrocarbons can be fixed to cellular proteins either by a bond or by two nonadjacent positions, then the experimental observations of Heidelberger and Moldenhauer can be understood.

The theory which has been proposed in this paper seems to indicate that it is rather improbable that there is a clear relation between the total amount of a substance which is fixed and its carcinogenic power; however, it remains probable that a necessary condition for a substance to be carcinogenic is that a substantial amount is fixed by one of its bonds to the protein.

Experiments have been suggested which should make it possible to test the value of the theory.

^* This work has been supported by grants No. C-3065 and C-524 from the National Cancer Institute, National Institutes of Health, to the Institute Pasteur.

Received 3/10/58.