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The Metabolism of 6-Thioguanine in Normal and Neoplastic Tissues^*

E. C. Moore and G. A. LePage

( McArdle Memorial Laboratory, Medical School, University of Wisconsin, Madison 6, Wis.)

6-Thioguanine was found to be rapidly absorbed from the blood stream by the tissues and rapidly eliminated in the urine. In tumor it was converted primarily to nucleotides; in intestine, liver, and bone marrow, approximately equal amounts of nucleotides and of thiouric acid were found. Tissue distribution and metabolites found with different times and doses were reported.

^* A preliminary report has appeared (11).

This research was supported in part by United States Public Health Service Grant No. C2491 and in part by the Alexander and Margaret Stewart Fund.

Present address: Department of Biochemistry, Univ. of Texas M.D. Anderson Hospital and Tumor Inst., Houston 25.

Present address: Dept. of Biological Sciences, Stanford Research Inst., Menlo Park, Calif.

Received 5/26/58.