This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cooper, J. R. Search for Related Content PubMed PubMed Citation Articles by Cooper, J. R.

Studies on 6-Uracil Methyl Sulfone

I. Nonenzymatic Metabolism

( Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.)

The fate of 6-uracil methyl sulfone in a liver homogenate has been studied with both chemical methods of assay and radioactivity measurements. The drug is metabolized by a nonenzymatic attack of sulfhydryl-containing compounds with a resultant loss of the -SO₂CH₃ group and the formation of a derivative of uracil in which the sulfurcontaining compound is exchanged for the group displaced.

Received 5/29/58.