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An Ovarian Teratocarcinoma as an Ascitic Tumor^*

( Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh 13, Pa.)

A teratocarcinoma of the ovary of a mouse, when converted to an ascitic form, lost its differentiated structures and became monocellular in type.

The monocellular tumor was shown to be a parietal yolk sac carcinoma. It had little or no morphogenetic propensity.

The evidence presented supports the contention that embryonal carcinoma is a stage in the development of teratocarcinomas.

^* This work was supported by U.S.P.H.S. Grant No. CY3297(C2) and The American Cancer Society Grant No. E-105.

This is publication No. 211 of the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh 13, Pennsylvania.

Markle Scholar in Medical Sciences.

Received 7/21/59.