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The Carcinogenicity of Fluoro Derivatives of 10-Methyl-1,2-benzanthracene

I. 3- and 4'-Monofluoro Derivatives^*

( McArdle Memorial Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison 6, Wis.)

Substitution of fluorine in the 3 position of the K region of 10-methyl-1,2-benzanthracene virtually abolished the carcinogenic activity of this hydrocarbon toward mouse skin and the subcutaneous tissues of rats and mice. Insertion of fluorine in the 4' position on the angular ring of the hydrocarbon produced a derivative highly toxic to rats and mice. No adequate tests of its carcinogenicity has been possible so far, although a single dose had moderate activity as an initiator of papillomas.

^* Supported by Grant C355 of the National Cancer Institute, United States Public Health Service, and by the Alexander and Margaret Stewart Trust Fund.

Received 8/ 5/59.