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Experimental Radiation Therapy of Tumors with I¹³¹-carrying Antibodies to Fibrin^*

( Department of Radiation Biology, University of Rochester School of Medicine and Dentistry, Rochester, N.Y.)

Antibody to rat fibrin, prepared from immunized rabbits and made radioactive by in vitro coupling with I¹³¹, localized with considerable specificity in several transplantable rat tumors after intravenous injection into rats bearing these tumors. Intravenous doses of 1.22–4.13 mc. of I¹³¹ attached to rat fibrin antibody, injected into rats bearing the transplantable Murphy-Sturm lymphosarcoma after the tumors had grown to 2–3 gm. in weight, consistently resulted in rapid and permanent regression of these tumors.

^* This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, N.Y.

Received 5/13/60.

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