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Effect of ß-3-Thienylalanine and Deoxypyridoxine on the Growth of the Murphy-Sturm Lymphosarcoma^*

Zdenek Hruban and Robert W. Wissler

( Department of Pathology, The University of Chicago, Chicago, Ill.)

Moderate growth inhibition was obtainable in several transplantable tumors by the feeding of ß-3-thienylalanine in diets lacking phenylalanine.

The effects of ß-3-thienylalanine and deoxypyridoxine were additive in inhibition of the growth of Murphy-Strum lymphosarcoma; this inhibition was further increased by testosterone, Halotestin, and Nilevar.

Small amounts of phenylpyruvate used with small doses of ß-3-thienylalanine and deoxypyridoxine appeared to be of greater advantage to the host than to the tumor.

^* Supported in part by Grant No. T-53A from the American Cancer Society and previously by Research Grant No. CF-7161 from the U.S. Public Health Service.

Public Health Service Research Fellow of the National Cancer Institute.

Received 6/14/60.