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A Study of Skin Carcinogenesis in the Mouse with Single Applications of 9,10-Dimethyl-1,2-benzanthracene at Different Dosages^*

( Division of Oncology, The Chicago Medical School, Chicago, Illinois)

Groups of female Swiss mice were treated with single applications of either 20, 50, 100, 200, 250, 500, or 1000 µg. of 9,10-dimethyl-1,2-benzanthracene in acetone on the skin of the interscapular area. Dose of 20 and 50 µg. did not give rise to epidermal carcinogenesis; a small number of benign papillomas was induced with a dose of 100 µg. Overt epidermal carcinogenesis, involving the induction of both benign and malignant tumors in a high proportion of animals, was detected at the 200-µg. dose level; above this dose no additional effect was noted. Many of the tumors induced eventually regressed, although a large number of those remaining became malignant. The results are discussed.

^* A preliminary report was presented at the meeting of the American Association for Cancer Research, Chicago, April, 1960.

This investigation was supported in part by Grant CS-9212 from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service. Dr. Terracini was supported in part by a scholarship from the Consiglio Nazionale delle Ricerche, Rome, Italy.

Received 6/16/60.