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Studies of Postcastrational Adrenal Cortical Changes in Parabiotic C3H Female Mice^*

( Department of Anatomy, University of Buffalo School of Medicine, Buffalo, N.Y.)

C3H female mice were joined in parabiosis for periods of 14 weeks and longer. Postcastrational adrenal changes, including nodular hyperplasia, were produced in intact mice by uniting them with spayed partners.

The gonadotropins produced by a mouse with nodular hyperplastic adrenals appear to be either quantitatively or qualitatively different from those produced by newly spayed mice. There is less ovarian hypertrophy in intact mice parabiosed to spayed mice with nodular hyperplastic adrenals than in similar mice joined to newly spayed partners. Uterine hypertrophy was the same in both groups.

Masculinization of the submaxillary gland was observed in most of the spayed mice and most of the intact mice joined to spayed partners.

^* This investigation was supported in part by research grant C-3409 from the National Cancer Institute, Public Health Service.

Received 5/13/60.