This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kokame, G. M. Articles by Wilson, J. K. Search for Related Content PubMed PubMed Citation Articles by Kokame, G. M. Articles by Wilson, J. K.

Studies on Transplantation and Behavior of Hamster Melanoma^*

Glenn M. Kokame, Edward T. Krementz and John K. Wilson

( Department of Surgery, Tulane University School of Medicine, New Orleans, La.)

The behavior of hamster melanoma after homologous transplantation to different sites has been studied. The relationship between transplanted tumor size, gross metastases, and circulating tumor cells was recorded. The variability of the heterotransplants, depending on the site of transfer and recipient animal, was noted. The following observations were made:

The hamster melanoma was readily transplantable to all attempted sites in the hamster. There was some tendency toward sarcomatous transformation upon homologous transplantation of the hamster melanoma. In hamsters bearing malignant melanoma transplants, circulating tumor cells in the blood stream could be detected only after gross metastases had appeared.

Heterologous transplantation was accomplished in the subcutaneous space of Swiss mice, peritoneal cavity of the guinea pig fetus, and the anterior chamber of guinea pigs' eyes.

^* This work was supported by grants from the American Cancer Society, Louisiana Division, Cancer Teaching Grant CT 762 (C10) from the National Cancer Institute of the National Institutes of Health, and the Anna Fuller Fund for Medical Research.

American Cancer Society Training Fellow.

American Cancer Society, Louisiana Division, Summer Student Research Fellow.

Received 5/31/60.